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Lineage divergence at the first TCR dependent checkpoint: preferential γδ and impaired αβ T cell development in non-obese diabetic (NOD) mice()
The first TCR-dependent checkpoint in the thymus determines αβ vs. γδ T lineage fate and sets the stage for later T cell differentiation decisions. We had previously shown that early T cells in NOD mice that are unable to rearrange a TCR exhibit a defect in checkpoint enforcement at this stage. To d...
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| Hlavní autoři: | , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2010
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4087166/ https://ncbi.nlm.nih.gov/pubmed/21148803 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1002630 |
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