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Hoechst Increases AAV-mediated Transgene Expression in Airway Epithelia by Inducing the CMV Promoter
BACKGROUND: In airway epithelia, the kinetics of recombinant adeno-associated virus (AAV) transgene expression is slow. This has negative practical implications for research and for translation into therapy. The DNA minor groove-binding agent Hoechst-33342 has been shown to enhance AAV transgene exp...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4086869/ https://ncbi.nlm.nih.gov/pubmed/22610695 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jgm.2632 |
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