Discovery of Biarylaminoquinazolines as Novel Tubulin Polymerization Inhibitors

[Image: see text] Cell cycle experiments with our previously reported 4-biphenylaminoquinazoline (1–3) multityrosine kinase inhibitors revealed an activity profile resembling that of known tubulin polymerization inhibitors. Novel 4-biarylaminoquinazoline analogues of compound 2 were synthesized and...

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Main Authors: Marzaro, Giovanni, Coluccia, Antonio, Ferrarese, Alessandro, Brun, Paola, Castagliuolo, Ignazio, Conconi, Maria Teresa, La Regina, Giuseppe, Bai, Ruoli, Silvestri, Romano, Hamel, Ernest, Chilin, Adriana
פורמט: Artigo
שפה:Inglês
יצא לאור: 2014
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Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4086859/
https://ncbi.nlm.nih.gov/pubmed/24801610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm500034j
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