Increased expression of glutamate transporter GLT-1 in peritumoral tissue associated with prolonged survival and decreases in tumor growth in a rat model of experimental malignant glioma: Laboratory investigation

OBJECT: Gliomas are known to release excessive amounts of glutamate, inducing glutamate excitotoxic cell death in the peritumoral region and allowing the tumor to grow and to expand. Glutamate transporter upregulation has been shown to be neuroprotective by removing extracellular glutamate in a numb...

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Detalhes bibliográficos
Main Authors: Sattler, Rita, Tyler, Betty, Hoover, Benjamin, Coddington, Luke T., Recinos, Violette, Hwang, Lee, Brem, Henry, Rothstein, Jeffrey D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4086647/
https://ncbi.nlm.nih.gov/pubmed/23909244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3171/2013.6.JNS122319
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