Combination of paclitaxel thermal gel depot with temozolomide and radiotherapy significantly prolongs survival in an experimental rodent glioma model

OncoGel™ incorporates paclitaxel, a mitotic inhibitor, into ReGel™, a thermosensitive gel depot system to provide local delivery, enhance efficacy and limit systemic toxicity. In previous studies the alkylating agent temozolomide (TMZ) incorporated into a polymer, pCPP:SA, also for local delivery, a...

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Detalhes bibliográficos
Main Authors: Vellimana, Ananth K., Recinos, Violette Renard, Hwang, Lee, Fowers, Kirk D., Li, Khan W., Zhang, Yonggang, Okonma, Saint, Eberhart, Charles G., Brem, Henry, Tyler, Betty M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4029109/
https://ncbi.nlm.nih.gov/pubmed/23224713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11060-012-1014-1
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