Co-administration of paroxetine and pravastatin causes deregulation of glucose homeostasis in diabetic rats via enhanced paroxetine exposure

AIM: Clinical evidence shows that co-administration of pravastatin and paroxetine deregulates glucose homeostasis in diabetic patients. The aim of this study was to verify this phenomenon in diabetic rats and to elucidate the underlying mechanisms. METHODS: Diabetes mellitus was induced in male SD r...

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Autors principals: Li, Feng, Zhang, Mian, Xu, Dan, Liu, Can, Zhong, Ze-yu, Jia, Ling-ling, Hu, Meng-yue, Yang, Yang, Liu, Li, Liu, Xiao-dong
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2014
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4086381/
https://ncbi.nlm.nih.gov/pubmed/24902787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2014.24
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