Co-administration of paroxetine and pravastatin causes deregulation of glucose homeostasis in diabetic rats via enhanced paroxetine exposure

AIM: Clinical evidence shows that co-administration of pravastatin and paroxetine deregulates glucose homeostasis in diabetic patients. The aim of this study was to verify this phenomenon in diabetic rats and to elucidate the underlying mechanisms. METHODS: Diabetes mellitus was induced in male SD r...

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Detalhes bibliográficos
Main Authors: Li, Feng, Zhang, Mian, Xu, Dan, Liu, Can, Zhong, Ze-yu, Jia, Ling-ling, Hu, Meng-yue, Yang, Yang, Liu, Li, Liu, Xiao-dong
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4086381/
https://ncbi.nlm.nih.gov/pubmed/24902787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2014.24
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