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Leptin protects mice from starvation-induced lymphoid atrophy and increases thymic cellularity in ob/ob mice

Thymic atrophy is a prominent feature of malnutrition. Forty-eight hours’ starvation of normal mice reduced the total thymocyte count to 13% of that observed in freely fed controls, predominantly because of a diminution in the cortical CD4(+)CD8(+) thymocyte subpopulation. Prevention of the fasting-...

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Autores principales: Howard, Jane K., Lord, Graham M., Matarese, Giuseppe, Vendetti, Silvia, Ghatei, Mohammad A., Ritter, Mary A., Lechler, Robert I., Bloom, Stephen R.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 1999
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC408574/
https://ncbi.nlm.nih.gov/pubmed/10525043
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