Leptin inhibits insulin gene transcription and reverses hyperinsulinemia in leptin-deficient ob/ob mice
Leptin controls feeding behavior and insulin secretion from pancreatic β-cells. Insulin stimulates the production of leptin, thereby establishing an adipoinsular axis. Earlier we identified leptin receptors on pancreatic β-cells and showed leptin-mediated inhibition of insulin secretion by activatio...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1999
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC15195/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9892692/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.2.674 |
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