Preferential coreceptor utilization and cytopathicity by dual-tropic HIV-1 in human lymphoid tissue ex vivo

Many HIV-1 isolates at the late stage of disease are capable of using both CXCR4 and CCR5 in transfected cell lines, and are thus termed dual-tropic. Here we asked whether these dual-tropic variants also use both coreceptors for productive infection in a natural human lymphoid tissue microenvironmen...

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Bibliografiske detaljer
Main Authors: Glushakova, Svetlana, Yi, Yanjie, Grivel, Jean-Charles, Singh, Anjali, Schols, Dominique, De Clercq, Erik, Collman, Ronald G., Margolis, Leonid
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 1999
Fag:
Rapid Publication
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC408546/
https://ncbi.nlm.nih.gov/pubmed/10487781
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