Preferential coreceptor utilization and cytopathicity by dual-tropic HIV-1 in human lymphoid tissue ex vivo

Many HIV-1 isolates at the late stage of disease are capable of using both CXCR4 and CCR5 in transfected cell lines, and are thus termed dual-tropic. Here we asked whether these dual-tropic variants also use both coreceptors for productive infection in a natural human lymphoid tissue microenvironmen...

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Bibliografiska uppgifter
I publikationen:J Clin Invest
Huvudupphovsmän: Glushakova, Svetlana, Yi, Yanjie, Grivel, Jean-Charles, Singh, Anjali, Schols, Dominique, De Clercq, Erik, Collman, Ronald G., Margolis, Leonid
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Clinical Investigation 1999
Ämnen:
Rapid Publication
Länkar:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC408546/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10487781/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI7403
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