RGS4 causes increased mortality and reduced cardiac hypertrophy in response to pressure overload

RGS family members are GTPase-activating proteins (GAPs) for heterotrimeric G proteins. There is evidence that altered RGS gene expression may contribute to the pathogenesis of cardiac hypertrophy and failure. We investigated the ability of RGS4 to modulate cardiac physiology using a transgenic mous...

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Autores principales: Rogers, Jason H., Tamirisa, Praveen, Kovacs, Attila, Weinheimer, Carla, Courtois, Michael, Blumer, Kendall J., Kelly, Daniel P., Muslin, Anthony J.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 1999
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC408537/
https://ncbi.nlm.nih.gov/pubmed/10487771
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