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Conservation in first introns is positively associated with the number of exons within genes and the presence of regulatory epigenetic signals

BACKGROUND: Genomes of higher eukaryotes have surprisingly long first introns and in some cases, the first introns have been shown to have higher conservation relative to other introns. However, the functional relevance of conserved regions in the first introns is poorly understood. Leveraging the r...

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Hlavní autoři: Park, Seung Gu, Hannenhalli, Sridhar, Choi, Sun Shim
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2014
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4085337/
https://ncbi.nlm.nih.gov/pubmed/24964727
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2164-15-526
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