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Anti-HIV IgA Isotypes: Differential Virion Capture and Inhibition of Transcytosis are Linked to Prevention of Mucosal R5 SHIV Transmission

OBJECTIVE: Although passive immunization with anti-HIV-1 Env IgG1 neutralizing monoclonal Abs (nmAbs) prevented simian-human immunodeficiency virus (SHIV) infection in rhesus monkeys (RMs), IgA nmAbs have not been tested. Here, we sought to determine whether human anti-HIV-1 dimeric (d)IgA1, dIgA2,...

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Detalhes bibliográficos
Main Authors: Watkins, Jennifer D., Sholukh, Anton M., Mukhtar, Muhammad M., Siddappa, Nagadenahalli B., Lakhashe, Samir K., Kim, Mikyung, Reinherz, Ellis L., Gupta, Sandeep, Forthal, Donald N., Sattentau, Quentin, Villinger, Francois, Corti, Davide, Ruprecht, Ruth M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4084966/
https://ncbi.nlm.nih.gov/pubmed/23775002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/QAD.0b013e328360eac6
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