An Anti-HIV-1 V3 Loop Antibody Fully Protects Cross-Clade and Elicits T-Cell Immunity in Macaques Mucosally Challenged with an R5 Clade C SHIV

Neutralizing antibodies have been shown to protect macaques against SHIV challenge. However, genetically diverse HIV-1 clades have evolved, and a key question left unanswered is whether neutralizing antibodies can confer cross-clade protection in vivo. The novel human monoclonal antibody HGN194 was...

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Main Authors: Watkins, Jennifer D., Siddappa, Nagadenahalli B., Lakhashe, Samir K., Humbert, Michael, Sholukh, Anton, Hemashettar, Girish, Wong, Yin Ling, Yoon, John K., Wang, Wendy, Novembre, Francis J., Villinger, Francois, Ibegbu, Chris, Patel, Kalpana, Corti, Davide, Agatic, Gloria, Vanzetta, Fabrizia, Bianchi, Siro, Heeney, Jonathan L., Sallusto, Federica, Lanzavecchia, Antonio, Ruprecht, Ruth M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3069056/
https://ncbi.nlm.nih.gov/pubmed/21483815
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0018207
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