Quantum proteolysis by neutrophils: implications for pulmonary emphysema in α(1)-antitrypsin deficiency

Traditional enzyme kinetics provide a poor explanation for the increased risk of lung injury in α(1)-antitrypsin (AAT) deficiency. Millimolar concentrations of leukocyte elastase, when released from single azurophil granules of activated neutrophils, lead to evanescent quantum bursts of proteolytic...

Ausführliche Beschreibung

Bibliografische Detailangaben

Veröffentlicht in:	J Clin Invest
Hauptverfasser:	Campbell, Edward J., Campbell, Melody A., Boukedes, Steve S., Owen, Caroline A.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Clinical Investigation 1999
Schlagworte:	Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC408416/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10430615/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI6092
Tags:	Tag hinzufügen Keine Tags, Fügen Sie das erste Tag hinzu!