Quantum proteolysis by neutrophils: implications for pulmonary emphysema in α(1)-antitrypsin deficiency

Traditional enzyme kinetics provide a poor explanation for the increased risk of lung injury in α(1)-antitrypsin (AAT) deficiency. Millimolar concentrations of leukocyte elastase, when released from single azurophil granules of activated neutrophils, lead to evanescent quantum bursts of proteolytic...

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Pubblicato in:	J Clin Invest
Autori principali:	Campbell, Edward J., Campbell, Melody A., Boukedes, Steve S., Owen, Caroline A.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Clinical Investigation 1999
Soggetti:	Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC408416/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10430615/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI6092
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