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Quantum proteolysis by neutrophils: implications for pulmonary emphysema in α(1)-antitrypsin deficiency
Traditional enzyme kinetics provide a poor explanation for the increased risk of lung injury in α(1)-antitrypsin (AAT) deficiency. Millimolar concentrations of leukocyte elastase, when released from single azurophil granules of activated neutrophils, lead to evanescent quantum bursts of proteolytic...
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| Autores principales: | , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
American Society for Clinical Investigation
1999
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC408416/ https://ncbi.nlm.nih.gov/pubmed/10430615 |
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