The Gly(972)→Arg amino acid polymorphism in IRS-1 impairs insulin secretion in pancreatic β cells

Eitemau Tebyg

• Association of IRS1 Gly972Arg and IRS2 Gly1057Asp polymorphisms with gastric cancer in Turkish subjects
  gan: Gorgisen, Gokhan, et al.
  Cyhoeddwyd: (2020)
• Transgenic mice overexpressing human G972R IRS-1 show impaired insulin action and insulin secretion.
  gan: Hribal, Marta L, et al.
  Cyhoeddwyd: (2008)
• Timp3 deficiency in insulin receptor–haploinsufficient mice promotes diabetes and vascular inflammation via increased TNF-α
  gan: Federici, Massimo, et al.
  Cyhoeddwyd: (2005)
• Prevalence of the insulin receptor substrate-1(IRS-1) Gly972Arg and the insulin receptor substrate-2(IRS-2) Gly1057Asp polymorphisms in PCOS patients and non-diabetic healthy women
  gan: Rashidi, Batool, et al.
  Cyhoeddwyd: (2011)
• The Gly(972)Arg Variant of Human IRS1 Gene Is Associated With Variation in Glomerular Filtration Rate Likely Through Impaired Insulin Receptor Signaling
  gan: Thameem, Farook, et al.
  Cyhoeddwyd: (2012)