The Gly(972)Arg Variant of Human IRS1 Gene Is Associated With Variation in Glomerular Filtration Rate Likely Through Impaired Insulin Receptor Signaling

The objective of this study is to identify and characterize the genetic variants related to the glomerular filtration rate (GFR) linkage on 2q37. Of the positional candidate genes, we selected IRS1 and resequenced its 2-kb promoter region and exons for sequence variants in 32 subjects. A total of 11...

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Detalhes bibliográficos
Main Authors: Thameem, Farook, Puppala, Sobha, Schneider, Jennifer, Bhandari, Basant, Arya, Rector, Arar, Nedal H., Vasylyeva, Tetyana L., Farook, Vidya S., Fowler, Sharon, Almasy, Laura, Blangero, John, Duggirala, Ravindranath, Abboud, Hanna E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2012
Assuntos:
Genetics/Genomes/Proteomics/Metabolomics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3425400/
https://ncbi.nlm.nih.gov/pubmed/22617042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db11-1078
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