The Gly(972)→Arg amino acid polymorphism in IRS-1 impairs insulin secretion in pancreatic β cells

Recent studies have identified several polymorphisms in the human insulin receptor substrate-1 (IRS-1) gene. The most prevalent IRS-1 variant, a Gly→Arg change at the codon 972, has been reported to be increased in prevalence among patients with type 2 diabetes. Carriers of the Arg(972) substitution...

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Hlavní autoři: Porzio, Ottavia, Federici, Massimo, Hribal, Marta Letizia, Lauro, Davide, Accili, Domenico, Lauro, Renato, Borboni, Patrizia, Sesti, Giorgio
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 1999
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC408413/
https://ncbi.nlm.nih.gov/pubmed/10430617
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