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Bruton’s Tyrosine Kinase Promotes Persistence of Mature Anti-Insulin B Cells
Autoreactive B lymphocytes are essential for the development of T cell–mediated type 1 diabetes (T1D). Cytoplasmic Bruton’s tyrosine kinase (BTK) is a key component of B cell signaling, and its deletion in T1D-prone NOD mice significantly reduces diabetes. However, the role of BTK in the survival an...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4083749/ https://ncbi.nlm.nih.gov/pubmed/24453243 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1300125 |
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