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Oligospermic infertility associated with an androgen receptor mutation that disrupts interdomain and coactivator (TIF2) interactions

Structural changes in the androgen receptor (AR) are one of the causes of defective spermatogenesis. We screened the AR gene of 173 infertile men with impaired spermatogenesis and identified 3 of them, unrelated, who each had a single adenine→guanine transition that changed codon 886 in exon 8 from...

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Udgivet i:J Clin Invest
Principais autores: Ghadessy, Farid J., Lim, Joyce, Abdullah, Abdullah A.R., Panet-Raymond, Valerie, Choo, Chee Keong, Lumbroso, Rose, Tut, Thein G., Gottlieb, Bruce, Pinsky, Leonard, Trifiro, Mark A., Yong, Eu Leong
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 1999
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Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC408364/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10359561/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI4289
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