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Oligospermic infertility associated with an androgen receptor mutation that disrupts interdomain and coactivator (TIF2) interactions

Structural changes in the androgen receptor (AR) are one of the causes of defective spermatogenesis. We screened the AR gene of 173 infertile men with impaired spermatogenesis and identified 3 of them, unrelated, who each had a single adenine→guanine transition that changed codon 886 in exon 8 from...

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Published in:J Clin Invest
Main Authors: Ghadessy, Farid J., Lim, Joyce, Abdullah, Abdullah A.R., Panet-Raymond, Valerie, Choo, Chee Keong, Lumbroso, Rose, Tut, Thein G., Gottlieb, Bruce, Pinsky, Leonard, Trifiro, Mark A., Yong, Eu Leong
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 1999
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Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC408364/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10359561/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI4289
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