Accelerated dissociation of IgE:FcεRI complexes by disruptive inhibitors actively desensitizes allergic effector cells

BACKGROUND: The remarkably stable interaction of immunoglobulin E (IgE) with its high-affinity receptor FcεRI on basophils and mast cells is critical for the induction of allergic hypersensitivity reactions. Due to the exceptionally slow dissociation rate of IgE:FcεRI complexes such allergic effecto...

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Main Authors: Eggel, Alexander, Baravalle, Günther, Hobi, Gabriel, Kim, Beomkyu, Buschor, Patrick, Forrer, Patrik, Shin, Jeoung-Sook, Vogel, Monique, Stadler, Beda M., Dahinden, Clemens A., Jardetzky, Theodore S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4083100/
https://ncbi.nlm.nih.gov/pubmed/24642143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2014.02.005
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