SUMOylation of ATRIP potentiates DNA damage signaling by boosting multiple protein interactions in the ATR pathway

The ATR (ATM [ataxia telangiectasia-mutated]- and Rad3-related) checkpoint is a crucial DNA damage signaling pathway. While the ATR pathway is known to transmit DNA damage signals through the ATR–Chk1 kinase cascade, whether post-translational modifications other than phosphorylation are important f...

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Detalhes bibliográficos
Main Authors: Wu, Ching-Shyi, Ouyang, Jian, Mori, Eiichiro, Nguyen, Hai Dang, Maréchal, Alexandre, Hallet, Alexander, Chen, David J., Zou, Lee
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2014
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4083090/
https://ncbi.nlm.nih.gov/pubmed/24990965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.238535.114
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