Targeted pancreatic cancer therapy with the small molecule drug conjugate SW IV‐134

Pancreatic adenocarcinoma is highly resistant to conventional therapeutics and has been shown to evade apoptosis by deregulation of the X‐linked and cellular inhibitors of apoptosis proteins (XIAP and cIAP). Second mitochondria‐derived activator of caspases (Smac) induces and amplifies cell death by...

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Hlavní autoři: Hashim, Yassar M., Spitzer, Dirk, Vangveravong, Suwanna, Hornick, Mary C., Garg, Gunjal, Hornick, John R., Goedegebuure, Peter, Mach, Robert H., Hawkins, William G.
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2014
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4082741/
https://ncbi.nlm.nih.gov/pubmed/24731702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molonc.2014.03.005
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