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Differential Effects of Ethanol on Spectral Binding and Inhibition of Cytochrome P450 3A4 with Eight Protease Inhibitors Antiretroviral Drugs

BACKGROUND: Cytochrome P450 3A4 (CYP3A4) is the most abundant CYP enzyme in the liver, which metabolizes approximately 50% of the marketed drugs including antiretroviral agents. CYP3A4 induction by ethanol and its impact on drug metabolism and toxicity is known. However, CYP3A4–ethanol physical inte...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Kumar, Santosh, Kumar, Anil
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2011
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4082664/
https://ncbi.nlm.nih.gov/pubmed/21682753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1530-0277.2011.01575.x
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