Heteropolymerization of S, I, and Z α(1)-antitrypsin and liver cirrhosis

The association between Z α(1)-antitrypsin deficiency and juvenile cirrhosis is well-recognized, and there is now convincing evidence that the hepatic inclusions are the result of entangled polymers of mutant Z α(1)-antitrypsin. Four percent of the northern European Caucasian population are heterozy...

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Pubblicato in:	J Clin Invest
Autori principali:	Mahadeva, Ravi, Chang, Wun-Shaing W., Dafforn, Timothy R., Oakley, Diana J., Foreman, Richard C., Calvin, Jacqueline, Wight, Derek G.D., Lomas, David A.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Clinical Investigation 1999
Soggetti:	Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC408255/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10194472/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI4874
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