α-Linoleic Acid Enhances the Capacity of α1-Antitrypsin to Inhibit Lipopolysaccharide-Induced IL-1β in Human Blood Neutrophils

Abstract Alphal-antitrypsin (A1AT, SERPINA1), a major circulating inhibitor of neutrophil elastase (NE) and protelnase-3 (PR3), has been proposed to reduce the processing and release of IL-1β. Since the antiinflammatory properties of A1AT are influenced by the presence of polyunsaturated fatty acids...

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Autors principals:	Nupur Aggarwal, Elena Korenbaum, Ravi Mahadeva, Stephan Immenschuh, Veronika Grau, Charles A Dinarello, Tobias Welte, Sabina Janciauskiene
Format:	Artigo
Idioma:	Inglês
Publicat:	BMC 2016-07-01
Col·lecció:	Molecular Medicine
Accés en línia:	http://link.springer.com/article/10.2119/molmed.2016.00119
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