Differential regulation of inotropy and lusitropy in overexpressed Gsα myocytes through cAMP and Ca(2+) channel pathways

We investigated the mechanisms responsible for altered contractile and relaxation function in overexpressed Gsα myocytes. Although baseline contractile function (percent contraction) in Gsα mice was similar to that of wild-type (WT) mice, left ventricular myocyte contraction, fura-2 Ca(2+)transients...

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Main Authors: Kim, Song-Jung, Yatani, Atsuko, Vatner, Dorothy E., Yamamoto, Satoshi, Ishikawa, Yoshihiro, Wagner, Thomas E., Shannon, Richard P., Kim, Young-Kwon, Takagi, Gen, Asai, Kuniya, Homcy, Charles J., Vatner, Stephen F.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 1999
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC408254/
https://ncbi.nlm.nih.gov/pubmed/10194482
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