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Withdrawal from chronic exposure to amphetamine, but not nicotine, leads to an immediate and enduring deficit in motivated behavior without affecting social interaction in rats

Psychostimulant withdrawal leads to depressive symptoms, such as anhedonia and social dysfunction. We determined the effects of withdrawal from chronic exposure to nicotine (9 mg/kg/day salt, 28 days) or amphetamine (10 mg/kg/day salt, 7 days) on the motivated response for a sucrose reward and on so...

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Detalhes bibliográficos
Main Authors: Der-Avakian, Andre, Markou, Athina
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4082429/
https://ncbi.nlm.nih.gov/pubmed/20571366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/FBP.0b013e32833c7cc8
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