Classification of a frameshift/extended and a stop mutation in WT1 as gain-of-function mutations that activate cell cycle genes and promote Wilms tumour cell proliferation

The WT1 gene encodes a zinc finger transcription factor important for normal kidney development. WT1 is a suppressor for Wilms tumour development and an oncogene for diverse malignant tumours. We recently established cell lines from primary Wilms tumours with different WT1 mutations. To investigate...

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Main Authors: Busch, Maike, Schwindt, Heinrich, Brandt, Artur, Beier, Manfred, Görldt, Nicole, Romaniuk, Paul, Toska, Eneda, Roberts, Stefan, Royer, Hans-Dieter, Royer-Pokora, Brigitte
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2014
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Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4082364/
https://ncbi.nlm.nih.gov/pubmed/24619359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddu111
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