PARG is dispensable for recovery from transient replicative stress but required to prevent detrimental accumulation of poly(ADP-ribose) upon prolonged replicative stress

Poly(ADP-ribosyl)ation is involved in numerous bio-logical processes including DNA repair, transcription and cell death. Cellular levels of poly(ADP-ribose) (PAR) are regulated by PAR polymerases (PARPs) and the degrading enzyme PAR glycohydrolase (PARG), controlling the cell fate decision between l...

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Main Authors: Illuzzi, Giuditta, Fouquerel, Elise, Amé, Jean-Christophe, Noll, Aurélia, Rehmet, Kristina, Nasheuer, Heinz-Peter, Dantzer, Françoise, Schreiber, Valérie
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2014
Assuntos:
Genome Integrity, Repair and Replication
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4081103/
https://ncbi.nlm.nih.gov/pubmed/24906880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku505
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