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A SET-domain-independent role of WRAD complex in cell-cycle regulatory function of mixed lineage leukemia
MLL, the trithorax ortholog, is a well-characterized histone 3 lysine 4 methyltransferase that is crucial for proper regulation of the Hox genes during embryonic development. Chromosomal translocations, disrupting the Mll gene, lead to aggressive leukemia with poor prognosis. However, the functions...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Oxford University Press
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4081079/ https://ncbi.nlm.nih.gov/pubmed/24880690 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku458 |
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