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The Pathogenesis of Mixed Lineage Leukemia
Aggressive leukemias arise in both children and adults as a result of rearrangements to the Mixed Lineage Leukemia (MLL) gene located on chromosome 11q23. The MLL gene encodes a large histone methyltransferase that directly binds and positively regulates gene transcription including HOX genes. MLL i...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3381338/ https://ncbi.nlm.nih.gov/pubmed/22017583 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1146/annurev-pathol-011811-132434 |
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