Force-induced melting of DNA—evidence for peeling and internal melting from force spectra on short synthetic duplex sequences

Overstretching of DNA occurs at about 60–70 pN when a torsionally unconstrained double-stranded DNA molecule is stretched by its ends. During the transition, the contour length increases by up to 70% without complete strand dissociation. Three mechanisms are thought to be involved: force-induced mel...

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Bibliografiska uppgifter
Huvudupphovsmän: Bosaeus, Niklas, El-Sagheer, Afaf H., Brown, Tom, Åkerman, Björn, Nordén, Bengt
Materialtyp: Artigo
Språk:Inglês
Publicerad: Oxford University Press 2014
Ämnen:
Structural Biology
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4081069/
https://ncbi.nlm.nih.gov/pubmed/24838568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku441
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