Divergent LIN28-mRNA associations result in translational suppression upon the initiation of differentiation

LIN28 function is fundamental to the activity and behavior of human embryonic stem cells (hESCs) and induced pluripotent stem cells. Its main roles in these cell types are the regulation of translational efficiency and let-7 miRNA maturation. However, LIN28-associated mRNA cargo shifting and resulta...

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Bibliographic Details
Main Authors: Tan, Shen Mynn, Altschuler, Gabriel, Zhao, Tian Yun, Ang, Haw Siang, Yang, Henry, Lim, Bing, Vardy, Leah, Hide, Winston, Thomson, Andrew M., Lareu, Ricky R.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2014
Subjects:
RNA
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4081066/
https://ncbi.nlm.nih.gov/pubmed/24860167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku430
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