Effects of arginine 10 to lysine substitution on ω-conotoxin CVIE and CVIF block of Ca(v)2.2 channels

BACKGROUND AND PURPOSE: ω-Conotoxins CVIE and CVIF (CVIE&F) selectively inhibit Ca(v)2.2 channels and are lead molecules in the development of novel analgesics. At physiological membrane potentials, CVIE&F block of Ca(v)2.2 channels is weakly reversible. To improve reversibility, we designed...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Berecki, G, Daly, N L, Huang, Y H, Vink, S, Craik, D J, Alewood, P F, Adams, D J
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2014
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4080983/
https://ncbi.nlm.nih.gov/pubmed/24628243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12686
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados