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γ-Aminobutyric Acid Type B (GABA(B)) Receptor Expression Is Needed for Inhibition of N-type (Ca(v)2.2) Calcium Channels by Analgesic α-Conotoxins
α-Conotoxins Vc1.1 and RgIA are small peptides isolated from the venom of marine cone snails. They have effective anti-nociceptive actions in rat models of neuropathic pain. Pharmacological studies in rodent dorsal root ganglion (DRG) show their analgesic effect is mediated by inhibition of N-type (...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3390670/ https://ncbi.nlm.nih.gov/pubmed/22613715 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.342998 |
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