γ-Aminobutyric Acid Type B (GABA(B)) Receptor Expression Is Needed for Inhibition of N-type (Ca(v)2.2) Calcium Channels by Analgesic α-Conotoxins

α-Conotoxins Vc1.1 and RgIA are small peptides isolated from the venom of marine cone snails. They have effective anti-nociceptive actions in rat models of neuropathic pain. Pharmacological studies in rodent dorsal root ganglion (DRG) show their analgesic effect is mediated by inhibition of N-type (...

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Bibliographische Detailangaben
Hauptverfasser: Cuny, Hartmut, de Faoite, Andrew, Huynh, Thuan G., Yasuda, Takahiro, Berecki, Géza, Adams, David J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2012
Schlagworte:
Neurobiology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3390670/
https://ncbi.nlm.nih.gov/pubmed/22613715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.342998
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