Development of Novel Major Histocompatibility Complex Class I and Class II-Deficient NOD-SCID IL2R Gamma Chain Knockout Mice for Modeling Human Xenogeneic Graft-Versus-Host Disease

Immunodeficient mice have been used as recipients of human peripheral blood mononuclear cells (PBMC) for in vivo analyses of human xeno-graft-versus-host disease (GVHD). This xeno-GVHD model system in many ways mimics the human disease. The model system is established by intravenous or intraperitone...

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Main Authors: Pino, Steve, Brehm, Michael A., Covassin-Barberis, Laurence, King, Marie, Chase, Thomas H., Wagner, Jennifer, Burzenski, Lisa, Foreman, Oded, Greiner, Dale L., Shultz, Leonard D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4080904/
https://ncbi.nlm.nih.gov/pubmed/20012395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/978-1-60761-058-8_7
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