Inhibitors of collagenase but not of gelatinase reduce cartilage explant proteoglycan breakdown despite only low levels of matrix metalloproteinase activity

Aims—To investigate the level of matrix metalloproteinase activity during the time-course of cartilage explant proteoglycan breakdown; to determine the effects of selective small-molecule inhibitors of matrix metalloproteinases on proteoglycan degradation. Methods—The levels of matrix metalloprotein...

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Publicat a:Clin Mol Pathol
Autors principals: Brown, Carol J, Rahman, Shamim, Morton, Allison C, Beauchamp, Claire L, Bramwell, Helena, Buttle, David J
Format: Artigo
Idioma:Inglês
Publicat: BMJ Publishing Group 1996
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Papers
Accés en línia:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC408083/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/16696099/
https://ncbi.nlm.nih.govhttps://doi.org/10.1136/mp.49.6.m331
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