Orally Available Small-Molecule Polymerase Inhibitor Cures a Lethal Morbillivirus Infection

Measles virus (MeV) is a highly infectious morbillivirus responsible for major human morbidity and mortality in the non-vaccinated. The related, zoonotic canine distemper virus (CDV) induces morbillivirus disease in ferrets with 100% lethality. We report an orally available, shelf-stable pan-morbill...

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Hlavní autoři: Krumm, Stefanie A, Yan, Dan, Hovingh, Elise S, Evers, Taylor J, Enkirch, Theresa, Reddy, G. Prabhakar, Sun, Aiming, Saindane, Manohar T, Arrendale, Richard F, Painter, George, Liotta, Dennis C, Natchus, Michael G, von Messling, Veronika, Plemper, Richard K
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4080709/
https://ncbi.nlm.nih.gov/pubmed/24739760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3008517
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