Requirement of Smurf-mediated endocytosis of Patched1 in sonic hedgehog signal reception

Cell surface reception of Sonic hedgehog (Shh) must ensure that the graded morphogenic signal is interpreted accordingly in neighboring cells to specify tissue patterns during development. Here, we report endocytic sorting signals for the receptor Patched1 (Ptch1), comprising two ‘PPXY’ motifs, that...

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Bibliografiska uppgifter
Huvudupphovsmän: Yue, Shen, Tang, Liu-Ya, Tang, Ying, Tang, Yi, Shen, Qiu-Hong, Ding, Jie, Chen, Yan, Zhang, Zengdi, Yu, Ting-Ting, Zhang, Ying E, Cheng, Steven Y
Materialtyp: Artigo
Språk:Inglês
Publicerad: eLife Sciences Publications, Ltd 2014
Ämnen:
Developmental Biology and Stem Cells
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4080449/
https://ncbi.nlm.nih.gov/pubmed/24925320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.02555
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