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Extreme HOT regions are CpG-dense promoters in C. elegans and humans
Most vertebrate promoters lie in unmethylated CpG-dense islands, whereas methylation of the more sparsely distributed CpGs in the remainder of the genome is thought to contribute to transcriptional repression. Nonmethylated CG dinucleotides are recognized by CXXC finger protein 1 (CXXC1, also known...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Cold Spring Harbor Laboratory Press
2014
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4079969/ https://ncbi.nlm.nih.gov/pubmed/24653213 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.161992.113 |
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