Altered amyloid precursor protein processing regulates glucose uptake and oxidation in cultured rodent myotubes

AIMS/HYPOTHESIS: Impaired glucose uptake in skeletal muscle is an important contributor to glucose intolerance in type 2 diabetes. The aspartate protease, beta-site APP-cleaving enzyme 1 (BACE1), a critical regulator of amyloid precursor protein (APP) processing, modulates in vivo glucose disposal a...

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Detalhes bibliográficos
Main Authors: Hamilton, D. Lee, Findlay, John A., Montagut, Gemma, Meakin, Paul J., Bestow, Dawn, Jalicy, Susan M., Ashford, Michael L. J.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4079947/
https://ncbi.nlm.nih.gov/pubmed/24849570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00125-014-3269-x
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