The Glucose Transporter Glut1 is Selectively Essential for CD4 T Cell Activation and Effector Function

CD4 T cell activation leads to rapid proliferation and differentiation into effector (Teff) or regulatory (Treg) cells that mediate or control immunity. While Teff and Treg prefer distinct glycolytic or oxidative metabolic programs in vitro, requirements and mechanisms that control T cell glucose up...

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Bibliografische gegevens
Hoofdauteurs: Macintyre, Andrew N., Gerriets, Valerie A., Nichols, Amanda G., Michalek, Ryan D., Rudolph, Michael C., Deoliveira, Divino, Anderson, Steven M., Abel, E. Dale, Chen, Benny J., Hale, Laura P., Rathmell, Jeffrey C.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2014
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4079750/
https://ncbi.nlm.nih.gov/pubmed/24930970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2014.05.004
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