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The RAD51-stimulatory compound RS-1 can exploit the RAD51 overexpression that exists in cancer cells and tumors

RAD51 is the central protein that catalyzes DNA repair via homologous recombination (HR), a process that ensures genomic stability. RAD51 protein is commonly expressed at high levels in cancer cells relative to their non-cancerous precursors. High levels of RAD51 expression can lead to the formation...

詳細記述

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書誌詳細
主要な著者: Mason, Jennifer M, Logan, Hillary L., Budke, Brian, Wu, Megan, Pawlowski, Michal, Weichselbaum, Ralph R., Kozikowski, Alan P., Bishop, Douglas K., Connell, Philip P.
フォーマット: Artigo
言語:Inglês
出版事項: 2014
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4079730/
https://ncbi.nlm.nih.gov/pubmed/24753542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-13-3220
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