Expression of the Genetic Suppressor Element 24.2 (GSE24.2) Decreases DNA Damage and Oxidative Stress in X-Linked Dyskeratosis Congenita Cells

The predominant X-linked form of Dyskeratosis congenita results from mutations in DKC1, which encodes dyskerin, a protein required for ribosomal RNA modification that is also a component of the telomerase complex. We have previously found that expression of an internal fragment of dyskerin (GSE24.2)...

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Main Authors: Manguan-Garcia, Cristina, Pintado-Berninches, Laura, Carrillo, Jaime, Machado-Pinilla, Rosario, Sastre, Leandro, Pérez-Quilis, Carme, Esmoris, Isabel, Gimeno, Amparo, García-Giménez, Jose Luis, Pallardó, Federico V., Perona, Rosario
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2014
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4079255/
https://ncbi.nlm.nih.gov/pubmed/24987982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0101424
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